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How a high fat ketogenic diet prevents diabetic ketoacidosis – somatostatin
Karl Petren 1868-1927How a high fat ketogenic diet prevents diabetic ketoacidosis – somatostatin It is pretty well-accepted now that nutritional ketosis and diabetic ketoacidosis are quite different...
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Japanese epidemiology puts another hole in the lipid hypothesis
Everyone is reading this masterful analysis (PDF) of the lipid hypothesis from Japan, a country where it doesn't even seem true, which hasn't stopped the Japanese authorities from recommending...
View ArticleStatins and cancer stories - the stupidest thing you'll read this week.
If this isn't the stupidest thing I've read since that "high-protein diets kill mice fed lots of casein, ergo humans shouldn't eat paleo diet (which a priori eliminates casein)" story last week.Statins...
View ArticleLee Hooper et al., 2015 - the latest Cochrane meta-analysis of saturated fat...
A new Cochrane meta-analysis of saturated fat reduction trials by Lee Hooper et al. has barely made a splash in the blogosphere, and my mention of it on Twitter barely merited a retweet.This is a pity,...
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Oliver and Boyd 1953 - lessons from the early history of the lipid hypothesis.
The introduction to Hooper et al. 2015 gives a good potted history of the lipid hypothesis. It's well worth reading to get some background as to why this idea that saturated fat causes heart disease...
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This Mendelian Randomisation - I think it does not mean what you think it means.
"LDL may or may not correlate to cardiovascular outcomes,”- Dr. Kim Allan Williams, president of the American College of Cardiologists“God, grant me the serenity to accept the things I cannot...
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How dairy fats and coconut protect against type 2 diabetes
Type 2 diabetes, in the etiology laid out by Professor Roy Taylor, is (in its usual form at any rate) a condition of fat accumulation in the pancreas, liver, and muscle cells, which causes insulin...
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Do moderate ketone levels from low carb protect against symptomatic...
Before many can know something, one must know it. - Dr Stockmann, in Ibsen's An Enemy of the People.One of the benefits of a very low carbohydrate diet for type 1 diabetes is a much lower rate of...
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Breastfeeding on a low carb diet - is there an increased risk of ketoacidosis?
[Disclaimer: I have never had a baby and have no practical experience of this subject. This blog post details the insights into this problem that can be found in the medical literature and is not...
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Medium Chain Fatty Acids and Brain Metabolism
This post relates in some way to each of the three previous posts.The definition of MCFA is a little unclear. Wikipedia lists lauric acid as a MCFA, making the range C:6-12, whereas commercial MCTs are...
View ArticleMy rant about David Katz's double identity and the meaning of consensus.
(I posted the first part of this rant on this RetractionWatch post but the moderator seems to have decided that it doesn't meet their policy. Fair enough as I find it hard to be restrained about such...
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FGF21 - a liver hormone linking sugar cravings and cardiovascular disease.
On Christmas Eve the media carried reports that scientists had identified a hormone, produced by the liver, that switches off sugar cravings, and which might be the answer to sugar addiction."Research...
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Saturated fat epidemiology - EPIC Netherlands and Malmö Diet and Cancer Study
The latest large epidemiologicial study on saturated fat and heart disease (IHD events) arrived yesterday. 35,597 people, followed for 12 years, suffered 1807 IHD events. It's called"The association...
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Good News from Melbourne University's NZO Mouse LCHF "Paleo" Study
The egregious behaviour of Prof Sol Andrikopoulos in his press release to global media has obscured the finding that was the primary purpose of the "Three Mouseketeers" study.The study was supposed to...
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The state of nutritional science, 2016
Someone sent me a link to this paper the other day, it's not something I would have looked at otherwise. However, next time you read a "totality of the evidence" snowjob supporting guidelines on...
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The Smoking Gun - the Role of PUFA in Non-Alcoholic Liver Disease
The smoking gunPublic health experts are gradually accepting the idea that sucrose and fructose are, like alcohol, causes of fatty liver disease (non-alcoholic liver disease - NAFLD - and its...
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Silymarin for type 2 diabetes - significant effects on glucose and lipids...
This study has an interesting backstory.Hepatitis C (mainly genotype 4) infects nearly a quarter of the Egyptian population. This is the highest rate of HCV infection I've heard of in any country;...
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On second thoughts, that vegetarian genomic study did show that not eating...
Generally, a study that purported to show that vegan and vegetarian diets are harmful would be welcomed by meat eaters, who get a lot of pseudoscientific criticism from members of those groups, some of...
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The Tragedy of William Stark, who conclusively proved that eating crap will...
How did I not know about William Stark MD?Born in Birmingham of an Irish mother and a Scottish father, he studied philosophy in Glasgow and medicine in Edinburgh and at the University of Leiden before...
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Mediterranean diet score in stable heart disease, and, more thoughts on...
This news article that made the rounds yesterday demonstrates how confirmation bias keeps the diet-heart hypothesis afloat.Healthy eating key to heart diseaseAfter 3.7 years' follow-up, a heart attack,...
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