A brief reading of the report of the new Kevin Hall study
Is the insulin theory of obesity over? Well I'd say it's over when people with diabetes using exogenous insulin to cover high-carb diets no longer have to worry about weight gain, and not before. But...
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Dietary fat type - saturated or unsaturated - does it make a difference to...
This is a section from a paper I'm writing about hepatic glycogen control, this part concerns the effect of dietary fat type on the insulin response. Spoiler alert: you will be surprised how little...
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#Context - Butter, eggs, and the epidemiology of cardiovascular disease and...
When Ancel Keys started work on his hypothesis, in 1955, he reported that butter only accounted for 4.8% of fats consumed in the USA.[1] Remember that. It’s well-known that eggs are associated with...
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Atkins, ketones, methylglyoxal and cancer
What you lose on the swings you make up for on the roundabouts.Recently this study enjoyed a bit a revival as it was used in a presentation at a DAA meet. I'm not sure of the exact context but the...
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This little piggy had none: are fat soluble micronutrients diluted by serum...
This will be a rambling post, I'm afraid, and more of a sketch of an idea rather than a pinning down.This excellent pig study, first tweeted by Prof Andro of the Suppversity blog, is clear proof that...
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Problems with Song et al Animal Protein vs Plant Protein study
According to Harvard, this truck has saved more lives than an ambulance. Here we have another study from the hydra-headed monster that is the Harvard school of public health's interpretation of the NHS...
View ArticleGlucokinase mutations, diabetic complications, and cardiovascular disease
This is a very interesting study that was posted by Richard Lehman on his BMJ blog a few years ago. It contains much food for thought.People with this mis-sense mutation in the gene that encodes...
View ArticleEvidence of cardiovascular benefits of LCHF diets, despite no change or...
A recent meta-analysis of low-carb diets and cardiovascular risk factors found, predictably, that low carb diets decrease triglycerides (TG), increase HDL, and - significantly, on average, but not...
View ArticleCourt of last appeal - the early history of the high-fat diet for diabetes
It's a long story, and not a proud one. Seeing an email in my inbox from the Journal of Diabetes & Metabolism, which seemed like the title of a journal I'd investigated earlier, I impulsively sent...
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Animal Protein vs Plant Protein - the illusion of scale in diet epidemiology.
This graph appeared in Jason Fung's excellent Intensive Dietary Management blog here. I don't really want to disagree with Jason's statement that animal protein raises insulin more than plant protein,...
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The HDL correlations in CANHEART probably don't mean what the druglords will...
The CANHEART study findings on HDL have made a big splash, supposedly debunking the idea that raising HDL is a good idea. Of course, raising HDL with drugs by sticking a spanner in the works at some...
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Scientific Fraud, in the Abstract
Someone posted this scare story from November in the Low Carb and Paleo group on Facebook.Luckily I missed it at the time as I was busy with arguably more important things, but being on holiday now I...
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Will a ketogenic diet increase the risk for malignant melanoma?
It's well-known that ketogenic diets reduce the growth of some cancer types in humans. These are early days for learning which cancer types are most vulnerable, which diet is best, and what the...
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Dietary Cholesterol and Hepatitis C
Dr Yu's group have produced (in 2015) a re-analysis of their diet data from the HALT-C study; the original paper, which led me to look into liver cholesterol mechanisms a few years back in the NASH...
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The role of silicon in health and disease - is this the whole grain...
You can say what you like about whole grains, but their bran provides an excellent means of concentrating the element silicon from the soil in an absorbable form.Silicon is required for the...
View ArticleCounsels of perfection
Counsels of perfectionA recent critique of the US dietary guidelines, which made some very good points about the failure to recommend that people stop eating processed foods, suggested that the phrase...
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Why the High-Fat Hep C Diet? Rationale and n=1 results.
I originally started this blog to publicise the hypothesis that a diet low in carbohydrate and linoleic acid, but high in saturated fat and long-chain PUFA, will inhibit HCV replication.The blog header...
View ArticleWhat I eat 2017
Another in the ever-popular genre of blog posts about what people eat.No photos though.I wake up and have an instant coffee with cream and 1/4 spoonful of dark brown sugar.Maybe I'll have another...
View ArticleBradford Hill is rolling in his grave
Austin Bradford Hill was, as should be well known, the father of modern epidemiology, who played a key role in determining a causal relationship between smoking and lung cancer.His 9 criteria (or...
View ArticleA Quick note on the ASCOT-LLA "Nocebo" statin side-effects study
Here's a comment I put on Malcolm Kendrick's post about the "statin side effects minimal" Lancet paper.For what it's worth, there's evidence that lipid lowering is effective in secondary prevention of...
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