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The Truth Was Still Putting on its Shoes - How Pseudoscience Came to Dominate...
Imagine you could restore health and lose weight by eating fats and protein and consuming fewer carbohydrates, i.e. sugar and grains. This was standard medical advice up until the late 1970s. Then the...
View ArticleOn What I Eat These Days
"I forget most of what I have read, just as I do most of what I have eaten, but I know that both contribute no less to the conservation of my mind and my body on that account." - Georg Christop...
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It Begins With Butter
The world at large will never be convinced of the benefits of low-carbohydrate diets until the still-vilified "saturated fat" is fully acquitted of the charges falsely laid in the courts of public...
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Cholesterol is a nutrient, not a food. Pork and cirrhosis revisited.
If HCV up-regulates HMG-CoA reductase, yet inhibits cholesterol completion, and if low cholesterol scores are associated with both hepatocellular cancer and poor response to treatment in people with...
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NASH - a Role for Dietary Cholesterol in Disease
"He knew, from many distinguished examples, how easily such a thing can become a mania, and how the most sober and balanced of men, once this passion is upon them, can lose completely their sense of...
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NASH and dietary cholesterol - the potted version
I thought I would summarize my thoughts about how a diabetogenic diet causes hepatic fibrosis and how the risk is increased by high intakes of dietary cholesterol in reasonably easy-to understand...
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Linoleic Acid (Omega 6 PUFA) promotes hepatic cholesterol accumulation -...
Deeply deranged, they said.From this paper: "Hepatic cholesterol accumulation is driven by a deeply deranged cellular cholesterol homeostasis, characterized by elevated cholesterol synthesis and uptake...
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A catch-all round-up grab-bag of stuff
To start with the latest on the story of linoleic acid and cholesterol, NAFLD and NASH; this PDF Effects of dietary cholesterol and fatty acids on plasma cholesterol level and hepatic lipoprotein...
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The Elegant Solution
Peter D has been running a fantastic series on PUFAs and cancer. Lots of references to linoleic acid promoting the growth of hepatoma cells."In the lab situation rapid hepatoma tumour growth needs...
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Gluten and Cross-Sensitivity as a Factor in Post-Interferon Malaise and...
(Music: Charlie Parker Live at Storyville, 1953)Coeliac and non-coeliac gluten sensitivity, conditions which can cause (apart from the classic syndrome) cirrhosis of the liver independent of viruses or...
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Carbs Will Be Carbs, or, The Mystery of The Polyol Pathway
This little paper should have made a minor splash in the paleosphere last week, but no-one really knew what to do with it. It has 20 authors. Success has a thousand fathers, they say. Endogenous...
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Hepatitis C Virus Replication is Glucose-Dependent
This blog exists to promote the hypothesis that carbohydrate restriction (plus the restriction of the omega 6 PUFA linoleic acid) is an effective antiviral strategy against Hepatitis C virus. Or...
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PCSK9, Alirocumab, and why high linoleic acid intakes increase vulnerability...
In ancient times, those suffering from ye surfeit of choleric humours were prescribed a purgative compounded of tincture of statin. Modern science, from its evidence-based wisdom, has compounded a new...
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How do you fix a leaky gut? New twists on old ideas.
Leaky gut, AKA intestinal permeability, is one of the determining factors in diseases of the liver, which should be tolerant of the normal adaptive quantities of lipopolysaccharides (LPS, fragments of...
View ArticleA Brief History of the Food Groups concept
"FOOD GROUP TO SPLIT - IRRECONCILABLE DIFFERENCES CITED" is a headline I expect to see any day now. The notion of the Food Group seems to have become the most abused concept in Nutrition. Two recent...
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Dr Richard Mackarness meets low-carb and Paleo pioneers in 1958
Dr Richard MackarnessIn Chapter 7 of his influential 1970's book on food allergies "Not All In The Mind" U.K. physician Dr Richard Mackarness describes his encounters with the pioneers of low-carb...
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More Junk Epidemiology - Cataracts and Vitamin C
This study on supplement use hasn't come up on the paleo radar, but it's a good example of how to expose junk epidemiology. It's from the Orthomolecular Medicine News Service - you can subscribe here...
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Metformin's unusual mechanisms - Lower Carb and Pro-Prebiotic
Metformin is generally considered to be a drug with few vices, so I was intrigued to read some tweets a while back that mentioned GI upsets in patients. Wikipedia lists these: "The most common adverse...
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What is a Maori Ancestral Diet?
Grant Schofield, Professor of Public Health at AUT, has done brilliant work bringing LCHF science to the mainstream media in New Zealand. To someone like myself, who enjoys science best when the most...
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The Maned Wolf - a lesson in deductive dentition
This is a South American canid, the Maned Wolf.This "dog" is a true omnivore, not unlike homo sapiens. It supplements a diet of meat (frogs, fish, lizards and other small game) with fruit, tubers, and...
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